Discover the Future of Web3: Insights, Innovations, and Interviews
Dive into the latest trends and expert perspectives in Web3, Blockchain, Crypto, and more with Sam Kamani. Join us as we explore the digital revolution shaping our world.

How Omnia Protocol Secured 4 Million Users: A Deep Dive with CTO Alex
In this episode of Web3 with Sam Kamani, we sit down with Alex, CTO and co-founder of Omnia Protocol, to explore how the team built secure and scalable Web3 infrastructure for millions of users. From combating front-running attacks to decentralizing node measurements, Alex shares tactical advice for builders, critical insights on the current landscape, and a clear vision for the future of Web3 infrastructure. Whether you're a developer, founder, or simply Web3-curious, this episode offers a rare peek behind the curtain of one of Web3’s most resilient infrastructure plays.

Unlocking web3's full potential with ankr: a conversation with tyler sloan
In this episode of Web3 with Sam Kamani, Tyler Sloan, Product Manager at Ankr, offers a deep dive into the critical role of infrastructure in the evolution of Web3. From RPC services to no-code rollup deployment, we unpack how Ankr is quietly shaping the future of decentralized development—without making developers jump through hoops. We also explore the company’s vision for staking within Bitcoin’s ecosystem, and what it really means to simplify blockchain for builders, businesses, and believers in decentralization.

Building DeFi on Bitcoin: Unlocking Layer 2 interoperability with Persistence
In this episode we talk with Jeroen Develter of Persistence about how they’re building intent-based architecture to simplify Bitcoin Layer 2 (L2) development. We explore the opportunities and roadblocks in making Bitcoin more usable for decentralized finance (DeFi), and how Persistence is positioning itself as a key interoperability layer in the Bitcoin ecosystem. From staking to DEX infrastructure, this episode is packed with thoughtful insights for builders, investors, and anyone curious about the next chapter of Bitcoin.
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Unlocking Bitcoin’s true potential with Native
In this episode, Siva and Robert—co-founders of Native—join Sam Kamani to explore how Native is building the application layer for Bitcoin. The conversation covers their transition from Ethereum, how they’re solving Bitcoin’s scalability and programmability limitations, their innovative zero-trust architecture, and the implications of a truly multi-chain future. With a testnet launch on the horizon and growing developer interest, Native is making a bold case for building directly on Bitcoin.

Bridging trust and tech: Blade Labs' blueprint for enterprise blockchain
In this episode of Web3 with Sam Kamani, Sami Mian, CEO and co-founder of Blade Labs, offers a grounded perspective on enterprise blockchain adoption. From interoperability challenges to regulatory foresight, this conversation breaks down what it truly takes to bring traditional finance into the Web3 world.

Breaking barriers in blockchain: lumio's vision for seamless cross-chain development
A deep-dive into episode 167 of Web3 with Sam Kamani featuring Alejo from Lumio and Pontem Network. This blog explores Lumio’s approach to enabling cross-chain deployment, the challenges of fragmented ecosystems, tokenization of real-world assets, and Alejo’s advice to Web3 developers.