Discover the Future of Web3: Insights, Innovations, and Interviews

Dive into the latest trends and expert perspectives in Web3, Blockchain, Crypto, and more with Sam Kamani. Join us as we explore the digital revolution shaping our world.

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How Simplify Labs Is Future-Proofing Crypto Exchanges in Europe

In this episode of Web3 with Sam Kamani, Vadym Rozov, founder of Simplify Labs, breaks down the coming wave of crypto regulation in Europe. With the Markets in Crypto Assets (MiCA) and DORA frameworks poised to reshape the continent’s crypto landscape, Simplify Labs is already ahead—offering modular, white-label infrastructure that’s regulation-ready. Vadym explains why only a fraction of Europe’s exchanges will survive, how his team built with compliance in mind from day one, and why banks are quickly becoming crypto-native. If you’re building a crypto product in the EU, this episode is essential listening.

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From black box to verifiable AI: how 0G.AI is building the decentralized AI operating system

In this episode of Web3 with Sam Kamani, Michael Heinrich, founder of 0G.AI, shares how his team is building a decentralized operating system for AI. With $350M raised, over 10 million wallets, and 500+ projects building on testnet, 0G is redefining what it means to run AI on-chain—solving the core challenges around trust, scalability, and alignment. If you're exploring the intersection of AI and blockchain, this conversation is a must-listen.

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The smartest wallet you’ve never used

Tychi Wallet is redefining what a crypto wallet can be. In Episode 266, Sam Kamani talks to founder Rishi about Tychi’s full-stack approach to self-custody—featuring AI tooling, social recovery, universal gas fees, and a built-in launchpad. With over 600 testers already onboard, the July launch promises to bring a smart, secure, and simplified experience to the Web3 world.

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Tokenizing oil as a security: how OilXCoin is bringing regulated RWAs to Web3

OilXCoin is doing what most crypto projects avoid: launching a fully regulated security token backed by real oil production. In this episode, Dave explains how they secured regulatory approval, built a product for crypto newcomers, and designed a compliant RWA model grounded in transparency, simplicity, and real-world economics.

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The missing backbone of Web3: Sergio on building enterprise-grade blockchain data infrastructure

In episode 264 of the Web3 with Sam Kamani podcast, Sergio Capanna—former AWS and Bloomberg product leader—dives into the deep, unglamorous, yet foundational work of blockchain data infrastructure. Now co-founder of Sonar X, Sergio is on a mission to fix Web3’s data layer by providing audit-grade, real-time, and historical cross-chain data to enterprises. From reconciling 30+ chains into standard schemas to making blockchain data accessible through Snowflake and Databricks, this conversation is a must-listen for anyone serious about Web3 scalability.

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Smart contracts can finally react: Rong Kai’s journey from police officer to Web3 builder

In this episode of Web3 with Sam Kamani, Rong Kai—co-founder of Reactive Network—shares his journey from serving in the Singapore Police Force to building one of the most promising infrastructure layers in Web3. Reactive Network introduces "reactive smart contracts" that can observe and respond to on-chain and cross-chain events, without relying on off-chain bots or centralized indexers. We explore what this means for devs, the current limitations of smart contracts, and how a $3M dev fund is fueling a smarter, modular blockchain future.

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